- What is Solensia?
- How does Solensia work?
- Why is targeting NGF a problem?
- What are the side effects of Solensia (including global adverse reactions' data)?
- When do the side effects occur?
- What can I do if my cat experiences side effects?
- When will Solensia be out of my cat's system?
- How can I report side effects and whom should I report them to?
- If not Solensia, then what? Are there any alternatives?
πΎ Downloads:
half-life calculator, alternative OA treatment guide, reporting side effects form with direct links/phones/emails
πΎ Links:
πΎ Solensia - side effects incl. reporting
πΎ Solensia - Information, Media Coverage, Class Action
πΎ Solensia & Librela - Product Recall Petitions (UK and USA)
πΎ Solensia - Share Your Story, Pet Loss Support
Solensia targets nerve growth factor (NGF), which plays a key role in transmitting pain signals to the brain. By binding to NGF, Solensia prevents it from attaching to its receptors on nerve cells, thereby interrupting pain signal transmission. However, Solensia does not treat the underlying osteoarthritis; it only addresses the pain. Therefore, if you choose to use Solensia, it is strongly recommended to support your catβs joints with appropriate supplementation as well.
Please note:
β οΈ Solensia was tested for 168 days, on 401 cats only (across two field studies).
As acknowledged by Zoetis' CEO during one of the interviews, Solensia's long-term effects of use remain officially unknown.
β οΈ The same interview revealed that Solensia should not be administered to cats with pre-existing neurological disorders, as it may aggravate the condition.
β οΈ Feedback from the pet owners indicates that Solensia should not be given to cats with pre-existing kidney disease, as it may aggravate the condition (contrary to the information provided in the product leaflet). Adverse reactions data (global) can be found below.
NGF plays a role far beyond pain signalingβit is crucial for the growth, maintenance, and survival of nerve cells in both the central and peripheral nervous systems. Additionally, NGF regulates the growth and differentiation of B-lymphocytes and supports the maturation of T-cells during infections, making it a key regulator of your catβs immune system. It is also essential for the maintenance and survival of pancreatic beta cells, which are responsible for insulin production, among many other vital functions. Targeting NGF can lead to devastating consequences in your cat's body. Solensia does not know which NGF transmit the pain, it targets them randomly, which can lead to various immune system and neurological system' issues.
The list of reported side effects associated with Solensia is extensive, including (but not limited to):
COMPLETE LIST OF REPORTED SIDE EFFECTS:
πΎ Solensia sADR data
πΎ FDA's detailed list of reported side effects (from January 2022 through June 2024)
β οΈ Due to the severity and scale of its side effects, Solensia should be considered only as an absolute last resortβnot a first option (or - ideally - not be considered at all). Before opting for Solensia, ensure you have explored all other available osteoarthritis treatments for your cat (see below).
It variesβsome cats experience them immediately, while for others, they may appear after months (or years) of use. This depends on several factors, including any pre-existing health conditions, existing medications (e.g., glucocorticoids), and the individual catβs level of NGF. Since NGF levels differ between cats, those with higher NGF may not exhibit side effects immediately but could develop them after several months of continuous injections.
Discontinue further injections immediately, as they may worsen the situation. Contact your veterinarian as soon as possible!
Please note:
β οΈ Solensia is not a "normal" drug, but a monoclonal antibody "treatment". Since it binds to your cat's NGF, it is impossible to flush it out of the system. You need to wait for it to decay.
In many cases, glucocorticoids (e.g., prednisolone, dexamethasone) may provide relief by suppressing your cat's immune system and increasing NGF levels, ergo lowering body's response to foreign "object" (Solensia), which minimizes the side effects (medical journal articles on steroids increasing NGF can be found in "media coverage").
Natual supplements like Lionβs Mane increase NGF as well.
In cats with naturally occurring osteoarthritis (OA), the half-life of frunevetmab has been determined to be approximately 10β12 days, ergo a full clearance from a single injection takes ~2.5 months; longer if more injections were given.
πΎ To assist you in estimating when Solensia may be fully cleared from your catβs system, we have created a Solensia Half-Life Calculator, available for download below (Excel format). Alternatively, you can open it in the Google Docs format here.
β οΈ For the United Kingdom π¬π§:
Please note, you can no longer report adverse reactions directly to VMD, but are required to report them to Zoetis, who must then report them to VMD within 30 days (more info on this can be found here).
To report adverse reactions to Zoetis, you can either:
For other countries:
Any side effects should be reported to Zoetis and the authorities. Reporting instructions, emails, phones, links to the forms etc. can be found here.
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Additionally, you can share your story on the "Solensia K*lled My Cat... Solensia - Class Action | LFPCSA" Facebook group to help raise awareness among other cat owners, or email us directly at help@lfpcsa.co.uk.
We would also greatly appreciate if you could please sign the petition to recall Solensia and Librela from the UK market.
Lastly, if you're interested in participating in the class action against Zoetis in the UK, you can sign up here.
All necessary links also grouped below.
Yes, there are numerous alternatives to consider:
β οΈ Please avoid purchasing generic "cold laser" devices from Amazon or eBay unless they are classified as medical devices, UKCA certified π¬π§, and registered with the MHRA π¬π§ (or meet the medical device certification and registration requirements in your country).
β οΈ In some cases, veterinarians may prescribe meloxicam for cats, but only under strict guidelines and for short-term use. Regular blood tests and monitoring of kidney function are essential to detect any early signs of toxicity.
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πΎ Full Guide to Alternative OA Treatment for Cats can be downloaded below.
Please always consult your veterinarian before introducing any new treatment to ensure itβs safe and appropriate for your cat's condition and overall health.
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Tags: Solensia information, Solensia side effects, Solensia adverse reactions, Solensia class action, LFPCSA Cambridge, Solensia killed my cat, Solensia danger, Solensia kidney disease, Solensia death, Solensia warning